| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | A | L | Bridgeport (OH) | 20 | Frontier (OH) (5) | 34 | Hx 666 | |
| 2021-08-28 | H | L | Bridgeport (OH) | 22 | Monroe Central (OH) (4) | 42 | Hx 688 | |
| 2021-09-03 | A | L | Bridgeport (OH) | 14 | Trinity (7) | 28 | Hx 440 | |
| 2021-09-11 | H | L | Bridgeport (OH) | 20 | Madonna (6) | 41 | Hx 414 | |
| 2021-09-24 | H | W | Bridgeport (OH) | 48 | Federal Hocking (OH) (0) | 0 | Hx 690 | |
| 2021-10-01 | H | W | Bridgeport (OH) | 40 | Beallsville (OH) (2) | 0 | Hx 679 | |
| 2021-10-08 | A | L | Bridgeport (OH) | 14 | River (OH) (6) | 50 | Hx 691 | |
| 2021-10-15 | A | L | Bridgeport (OH) | 6 | Shadyside (OH) (8) | 51 | Hx 692 | |
| 2021-10-22 | A | W | Bridgeport (OH) | 50 | Paden City (2) | 8 | Hx 433 |