| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Paden City | 0 | Frontier (OH) (5) | 34 | Hx 430 | |
| 2021-09-03 | A | W | Paden City | 58 | Hancock (MD) (1) | 0 | Hx 431 | |
| 2021-09-10 | A | L | Paden City | 14 | Montcalm (2) | 20 | Hx 574 | |
| 2021-09-24 | A | W | Paden City | 55 | Hundred (0) | 0 | Hx 531 | |
| 2021-10-01 | H | L | Paden City | 13 | Calhoun County (2) | 44 | Hx 475 | |
| 2021-10-06 | H | L | Paden City | 0 | Trinity (7) | 1 | Hx 588 | |
| 2021-10-15 | A | L | Paden City | 14 | Beallsville (OH) (2) | 40 | Hx 432 | |
| 2021-10-22 | H | L | Paden City | 8 | Bridgeport (OH) (3) | 50 | Hx 433 | |
| 2021-10-29 | A | L | Paden City | 12 | Webster County (2) | 21 | Hx 589 | |
| 2021-11-05 | H | L | Paden City | 20 | Valley-Wetzel (3) | 46 | Hx 590 |