| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | H | W | Racine Southern (OH) | 37 | Federal Hocking (OH) (0) | 8 | Hx 1131 | |
| 2021-09-04 | H | L | Racine Southern (OH) | 0 | Frontier (OH) (5) | 33 | Hx 1141 | |
| 2021-09-10 | A | W | Racine Southern (OH) | 57 | South Gallia (OH) (0) | 22 | Hx 777 | |
| 2021-09-17 | H | W | Racine Southern (OH) | 73 | Belpre (OH) (1) | 36 | Hx 778 | |
| 2021-09-24 | H | L | Racine Southern (OH) | 0 | Trinity (7) | 30 | Hx 442 | |
| 2021-10-01 | H | L | Racine Southern (OH) | 0 | Waterford (OH) (6) | 55 | Hx 781 | |
| 2021-10-09 | A | W | Racine Southern (OH) | 35 | Manchester (OH) (1) | 14 | Hx 739 | |
| 2021-10-15 | A | L | Racine Southern (OH) | 0 | Trimble (OH) (7) | 34 | Hx 779 | |
| 2021-10-23 | H | L | Racine Southern (OH) | 14 | Reedsville Eastern (OH) (4) | 41 | Hx 780 |