| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Tygarts Valley | 49 | Valley-Wetzel () | 0 | 628 | |
| 2021-09-03 | A | L | Tygarts Valley | 14 | Tucker County () | 16 | 625 | |
| 2021-09-10 | A | W | Tygarts Valley | 43 | Webster County () | 14 | 627 | |
| 2021-09-17 | A | L | Tygarts Valley | 14 | East Hardy () | 30 | 500 | |
| 2021-09-24 | H | L | Tygarts Valley | 30 | Clay-Battelle () | 36 | 488 | |
| 2021-10-01 | H | W | Tygarts Valley | 41 | Richwood () | 16 | 607 | |
| 2021-10-08 | A | L | Tygarts Valley | 14 | Pendleton County () | 21 | 593 | |
| 2021-10-22 | A | L | Tygarts Valley | 14 | Trinity () | 21 | 570 | |
| 2021-10-29 | H | W | Tygarts Valley | 20 | Pocahontas County () | 0 | 600 | |
| 2021-11-05 | H | L | Tygarts Valley | 0 | Doddridge County () | 34 | 497 |