| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | South Harrison | 0 | Doddridge County () | 20 | 490 | |
| 2021-09-03 | A | W | South Harrison | 30 | Liberty-Harrison () | 7 | 300 | |
| 2021-09-10 | H | L | South Harrison | 0 | Tyler Consolidated () | 40 | 618 | |
| 2021-09-17 | H | L | South Harrison | 20 | Grafton () | 28 | 266 | |
| 2021-09-24 | H | L | South Harrison | 20 | Gilmer County () | 39 | 509 | |
| 2021-10-01 | A | W | South Harrison | 26 | Valley-Wetzel () | 6 | 619 | |
| 2021-10-08 | H | L | South Harrison | 20 | Ritchie County () | 50 | 613 | |
| 2021-10-22 | A | L | South Harrison | 6 | St. Marys () | 41 | 620 | |
| 2021-10-29 | H | W | South Harrison | 44 | Braxton County () | 14 | 218 | |
| 2021-11-05 | A | W | South Harrison | 36 | Tucker County () | 24 | 621 |