| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Greenbrier West | 20 | Buffalo () | 21 | 1 OT461 | |
| 2021-09-03 | A | W | Greenbrier West | 20 | Summers County () | 8 | 513 | |
| 2021-09-10 | H | W | Greenbrier West | 32 | Pocahontas County () | 0 | 517 | |
| 2021-09-17 | H | W | Greenbrier West | 58 | Webster County () | 6 | 515 | |
| 2021-10-01 | A | W | Greenbrier West | 51 | Meadow Bridge () | 12 | 516 | |
| 2021-10-08 | H | L | Greenbrier West | 14 | James Monroe () | 20 | 514 | |
| 2021-10-15 | A | W | Greenbrier West | 50 | Richwood () | 8 | 518 | |
| 2021-10-22 | A | W | Greenbrier West | 38 | Sherman () | 8 | 519 | |
| 2021-10-29 | H | L | Greenbrier West | 8 | Midland Trail () | 33 | 520 | |
| 2021-11-05 | H | L | Greenbrier West | 14 | Mt. View () | 18 | 521 | |
| 2021-11-13 | A | L | Greenbrier West | 20 | Williamstown () | 48 | 6-11 1st RD | 1271 |