| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Midland Trail | 21 | Clay County () | 22 | 230 | |
| 2021-09-03 | H | W | Midland Trail | 34 | Tolsia () | 20 | 556 | |
| 2021-09-10 | H | W | Midland Trail | 33 | Meadow Bridge () | 0 | 551 | |
| 2021-10-01 | H | L | Midland Trail | 22 | Nicholas County () | 47 | 332 | |
| 2021-10-08 | H | L | Midland Trail | 21 | Independence () | 60 | 285 | |
| 2021-10-15 | A | L | Midland Trail | 7 | James Monroe () | 20 | 538 | |
| 2021-10-18 | A | W | Midland Trail | 35 | Summers County () | 14 | 1184 | |
| 2021-10-22 | A | W | Midland Trail | 41 | Richwood () | 2 | 557 | |
| 2021-10-29 | A | W | Midland Trail | 33 | Greenbrier West () | 8 | 520 | |
| 2021-11-05 | H | W | Midland Trail | 42 | Pocahontas County () | 6 | 559 | |
| 2021-11-12 | A | L | Midland Trail | 21 | Doddridge County () | 40 | 2-15 1st RD | 1268 |