| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Buffalo | 21 | Greenbrier West () | 20 | 1 OT461 | |
| 2021-09-17 | H | L | Buffalo | 6 | Williamstown () | 49 | 463 | |
| 2021-09-25 | H | L | Buffalo | 3 | Roane County () | 22 | 378 | |
| 2021-10-01 | A | L | Buffalo | 6 | Man () | 20 | 464 | |
| 2021-10-08 | A | L | Buffalo | 0 | Tyler Consolidated () | 35 | 465 | |
| 2021-10-15 | A | W | Buffalo | 47 | Tolsia () | 6 | 466 | |
| 2021-10-22 | H | W | Buffalo | 26 | Ravenswood () | 21 | 467 | |
| 2021-10-29 | A | W | Buffalo | 27 | Van () | 0 | 468 | |
| 2021-11-05 | H | W | Buffalo | 20 | Wahama () | 14 | 469 |