| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-26 | A | L | Hedgesville | 0 | Washington () | 20 | 88 | |
| 2021-09-03 | H | W | Hedgesville | 14 | Warren County (VA) () | 12 | 89 | |
| 2021-09-10 | H | W | Hedgesville | 28 | East Fairmont () | 0 | 90 | |
| 2021-09-17 | A | L | Hedgesville | 20 | Morgantown () | 62 | 91 | |
| 2021-09-24 | H | L | Hedgesville | 6 | Martinsburg () | 54 | 92 | |
| 2021-10-01 | A | W | Hedgesville | 20 | Spring Mills () | 7 | 93 | |
| 2021-10-08 | H | L | Hedgesville | 0 | Musselman () | 35 | 94 | |
| 2021-10-15 | H | L | Hedgesville | 16 | Princeton () | 21 | 95 | |
| 2021-10-29 | A | L | Hedgesville | 7 | Jefferson () | 43 | 96 | |
| 2021-11-06 | A | W | Hedgesville | 34 | Hampshire () | 21 | 87 |