| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | W | Musselman | 56 | Spring Mills (3) | 23 | Hx 157 | |
| 2021-09-03 | H | L | Musselman | 14 | Martinsburg (13) | 56 | Hx 133 | |
| 2021-09-10 | H | L | Musselman | 12 | Jefferson (10) | 47 | Hx 110 | |
| 2021-09-17 | H | L | Musselman | 43 | Sherando (VA) (5) | 49 | Hx 145 | |
| 2021-10-01 | A | L | Musselman | 14 | Morgantown (5) | 34 | Hx 141 | |
| 2021-10-08 | A | W | Musselman | 35 | Hedgesville (3) | 0 | Hx 94 | |
| 2021-10-15 | H | W | Musselman | 25 | Wheeling Park (3) | 17 | Hx 158 | |
| 2021-10-22 | A | L | Musselman | 28 | Washington (5) | 29 | Hx 159 | |
| 2021-10-29 | A | L | Musselman | 27 | Bridgeport (8) | 63 | Hx 27 | |
| 2021-11-05 | H | L | Musselman | 52 | Parkersburg (4) | 56 | Hx 10 |