| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Hampshire | 21 | Preston (1) | 0 | Hx 79 | |
| 2021-09-03 | A | L | Hampshire | 8 | Frankfort (6) | 21 | Hx 80 | |
| 2021-09-10 | H | L | Hampshire | 7 | Spring Mills (3) | 51 | Hx 81 | |
| 2021-09-17 | A | W | Hampshire | 69 | Park View-Sterling (VA) (0) | 37 | Hx 82 | |
| 2021-09-24 | H | L | Hampshire | 14 | Keyser (4) | 50 | Hx 83 | |
| 2021-10-08 | A | W | Hampshire | 35 | Petersburg (3) | 14 | Hx 84 | |
| 2021-10-15 | A | L | Hampshire | 40 | Berkeley Springs (4) | 71 | Hx 85 | |
| 2021-10-22 | H | L | Hampshire | 6 | Greenbrier East (6) | 56 | Hx 76 | |
| 2021-10-29 | H | L | Hampshire | 0 | Washington (5) | 1 | Hx 86 | |
| 2021-11-06 | H | L | Hampshire | 21 | Hedgesville (3) | 34 | Hx 87 |