| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | L | Morgantown | 28 | South Charleston (5) | 37 | Hx 139 | |
| 2021-09-03 | A | L | Morgantown | 20 | Bridgeport (8) | 31 | Hx 21 | |
| 2021-09-17 | H | W | Morgantown | 62 | Hedgesville (3) | 20 | Hx 91 | |
| 2021-09-24 | A | L | Morgantown | 27 | Woodrow Wilson (4) | 28 | 1 OT Hx 140 | |
| 2021-10-01 | H | W | Morgantown | 34 | Musselman (3) | 14 | Hx 141 | |
| 2021-10-08 | H | L | Morgantown | 6 | Wheeling Park (3) | 41 | Hx 142 | |
| 2021-10-15 | H | W | Morgantown | 21 | Parkersburg South (5) | 14 | Hx 16 | |
| 2021-10-22 | A | W | Morgantown | 33 | John Marshall (3) | 7 | Hx 121 | |
| 2021-10-29 | A | L | Morgantown | 14 | University (10) | 49 | Hx 143 | |
| 2021-11-05 | A | W | Morgantown | 49 | Spring Mills (3) | 13 | Hx 144 | |
| 2021-11-12 | A | L | Morgantown | 7 | Bridgeport (8) | 34 | 3-14 1st RD | Hx 1286 |