| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-30 | H | L | Lewis County | 22 | Fairmont Sr. () | 47 | 253 | |
| 2021-09-03 | A | L | Lewis County | 22 | Braxton County () | 38 | 212 | |
| 2021-09-10 | H | W | Lewis County | 22 | Elkins () | 8 | 246 | |
| 2021-09-20 | A | L | Lewis County | 0 | Roane County () | 55 | 296 | |
| 2021-10-01 | H | L | Lewis County | 6 | Lincoln () | 21 | 297 | |
| 2021-10-08 | A | L | Lewis County | 14 | Buckhannon-Upshur () | 31 | 43 | |
| 2021-10-15 | A | L | Lewis County | 7 | North Marion () | 37 | 298 | |
| 2021-10-22 | H | W | Lewis County | 52 | Philip Barbour () | 21 | 299 | |
| 2021-10-29 | H | L | Lewis County | 18 | East Fairmont () | 34 | 242 | |
| 2021-11-05 | A | L | Lewis County | 6 | Grafton () | 48 | 270 |