| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | L | Buckhannon-Upshur | 0 | Bridgeport (8) | 1 | Hx 20 | |
| 2021-09-03 | A | L | Buckhannon-Upshur | 13 | Ripley (1) | 31 | Hx 39 | |
| 2021-09-10 | A | W | Buckhannon-Upshur | 27 | Philip Barbour (1) | 16 | Hx 40 | |
| 2021-09-17 | A | L | Buckhannon-Upshur | 14 | Greenbrier East (6) | 56 | Hx 41 | |
| 2021-10-01 | H | L | Buckhannon-Upshur | 14 | John Marshall (3) | 33 | Hx 42 | |
| 2021-10-08 | H | W | Buckhannon-Upshur | 31 | Lewis County (2) | 14 | Hx 43 | |
| 2021-10-15 | H | L | Buckhannon-Upshur | 6 | University (10) | 63 | Hx 44 | |
| 2021-10-22 | A | L | Buckhannon-Upshur | 14 | Grafton (5) | 47 | Hx 45 | |
| 2021-10-29 | H | L | Buckhannon-Upshur | 14 | Preston (1) | 30 | Hx 46 | |
| 2021-11-05 | A | W | Buckhannon-Upshur | 33 | Elkins (0) | 6 | Hx 47 |