| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-30 | H | L | Elkins | 6 | Liberty-Harrison () | 33 | 244 | |
| 2021-09-03 | A | L | Elkins | 0 | Robert C. Byrd () | 57 | 245 | |
| 2021-09-10 | A | L | Elkins | 8 | Lewis County () | 22 | 246 | |
| 2021-09-24 | A | L | Elkins | 20 | Philip Barbour () | 49 | 247 | |
| 2021-10-01 | H | L | Elkins | 13 | Grafton () | 46 | 248 | |
| 2021-10-08 | H | L | Elkins | 7 | North Marion () | 53 | 249 | |
| 2021-10-15 | A | L | Elkins | 0 | Lincoln () | 1 | 250 | |
| 2021-10-22 | A | L | Elkins | 0 | Frankfort () | 53 | 251 | |
| 2021-10-29 | A | L | Elkins | 0 | Fairmont Sr. () | 53 | 252 | |
| 2021-11-05 | H | L | Elkins | 6 | Buckhannon-Upshur () | 33 | 47 |