| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | W | Frankfort | 19 | Moorefield (7) | 0 | Hx 259 | |
| 2021-09-03 | H | W | Frankfort | 21 | Hampshire (2) | 8 | Hx 80 | |
| 2021-09-10 | H | W | Frankfort | 21 | Washington (5) | 0 | Hx 192 | |
| 2021-09-17 | H | W | Frankfort | 67 | Berkeley Springs (4) | 26 | Hx 198 | |
| 2021-09-24 | A | L | Frankfort | 6 | Northern Garrett County (MD) (4) | 28 | Hx 260 | |
| 2021-10-01 | H | L | Frankfort | 13 | Mt. Ridge (MD) (7) | 48 | Hx 261 | |
| 2021-10-08 | A | L | Frankfort | 20 | Spring Mills (3) | 21 | Hx 186 | |
| 2021-10-22 | H | W | Frankfort | 53 | Elkins (0) | 0 | Hx 251 | |
| 2021-10-29 | A | L | Frankfort | 19 | North Marion (8) | 42 | Hx 262 | |
| 2021-11-05 | A | W | Frankfort | 41 | Keyser (4) | 35 | Hx 263 | |
| 2021-11-12 | A | W | Frankfort | 21 | Lincoln (8) | 17 | 4-13 1st RD | Hx 1274 |
| 2021-11-20 | A | L | Frankfort | 49 | Poca (9) | 56 | Quarterfinals | Hx 1299 |