| Date | H/A | W/L | Team | Score | Opponent | Score | |||
| 2021-03-05 | A | L | Roane County | 54 | Webster County | 78 | 757 | ||
| 2021-03-06 | H | W | Roane County | 60 | Sissonville | 38 | 758 | ||
| 2021-03-09 | A | L | Roane County | 33 | Clay County | 58 | 63 | ||
| 2021-03-11 | A | L | Roane County | 53 | Braxton County | 68 | 22 | ||
| 2021-03-13 | H | W | Roane County | 72 | Parkersburg Catholic | 41 | 761 | ||
| 2021-03-16 | H | W | Roane County | 77 | Calhoun County | 36 | 759 | ||
| 2021-03-18 | A | L | Roane County | 50 | Gilmer County | 54 | 137 | ||
| 2021-03-20 | H | L | Roane County | 45 | Buffalo | 52 | 1 OT | 760 | |
| 2021-03-23 | H | L | Roane County | 44 | South Harrison | 57 | 762 | ||
| 2021-03-25 | A | W | Roane County | 58 | Doddridge County | 39 | 80 | ||
| 2021-03-27 | A | L | Roane County | 33 | Ravenswood | 41 | 756 | ||
| 2021-03-29 | H | W | Roane County | 82 | Webster County | 81 | 3 OT | 763 | |
| 2021-04-01 | H | L | Roane County | 43 | Clay County | 60 | 764 | ||
| 2021-04-03 | H | W | Roane County | 57 | Ravenswood | 47 | 1 OT | 755 | |
| 2021-04-06 | H | L | Roane County | 59 | Braxton County | 64 | 765 | ||
| 2021-04-08 | H | W | Roane County | 62 | Wirt County | 38 | LKC 11th | 1126 | |
| 2021-04-12 | A | L | Roane County | 36 | Charleston Catholic | 78 | 60 | ||
| 2021-04-16 | A | L | Roane County | 59 | Buffalo | 70 | 43 | ||
| 2021-04-21 | A | W | Roane County | 47 | Ravenswood | 43 | 1192 | ||
| 2021-04-23 | A | L | Roane County | 28 | Charleston Catholic | 91 | 1238 | ||
| 2021-04-29 | A | L | Roane County | 31 | Poca | 75 | 1279 |