| Date | H/A | W/L | Team | Score | Opponent | Score | |||
| 2021-03-16 | A | L | Calhoun County | 36 | Roane County | 77 | 759 | ||
| 2021-03-19 | H | L | Calhoun County | 34 | Ritchie County | 61 | 733 | ||
| 2021-03-20 | A | L | Calhoun County | 22 | Man | 93 | 782 | ||
| 2021-03-22 | H | L | Calhoun County | 23 | South Harrison | 75 | 783 | ||
| 2021-03-23 | A | L | Calhoun County | 44 | Braxton County | 83 | 24 | ||
| 2021-03-25 | H | L | Calhoun County | 19 | Clay County | 62 | 780 | ||
| 2021-03-27 | A | L | Calhoun County | 32 | Doddridge County | 69 | 77 | ||
| 2021-03-31 | A | L | Calhoun County | 28 | Gilmer County | 84 | 136 | ||
| 2021-04-01 | A | L | Calhoun County | 40 | South Harrison | 90 | 787 | ||
| 2021-04-03 | H | L | Calhoun County | 26 | Wirt County | 70 | 717 | ||
| 2021-04-05 | H | L | Calhoun County | 50 | Man | 93 | 788 | ||
| 2021-04-06 | H | L | Calhoun County | 45 | Gilmer County | 73 | 789 | ||
| 2021-04-08 | H | W | Calhoun County | 48 | Parkersburg Catholic | 43 | LKC 15th | 1128 | |
| 2021-04-09 | H | L | Calhoun County | 35 | Doddridge County | 43 | 1141 | ||
| 2021-04-12 | A | L | Calhoun County | 33 | Ritchie County | 68 | 735 | ||
| 2021-04-15 | A | L | Calhoun County | 40 | Wirt County | 74 | 716 | ||
| 2021-04-20 | A | L | Calhoun County | 38 | Gilmer County | 49 | 1205 |