| Date | H/A | W/L | Team | Score | Opponent | Score | |||
| 2021-03-05 | H | L | Wirt County | 27 | Ravenswood | 56 | 706 | ||
| 2021-03-08 | A | W | Wirt County | 49 | Wood Co. Christian | 33 | 708 | ||
| 2021-03-09 | A | L | Wirt County | 54 | Parkersburg Catholic | 71 | 683 | ||
| 2021-03-11 | A | L | Wirt County | 33 | Wahama | 61 | 710 | ||
| 2021-03-15 | H | L | Wirt County | 32 | Magnolia | 69 | 712 | ||
| 2021-03-16 | H | L | Wirt County | 42 | Ritchie County | 66 | 713 | ||
| 2021-03-18 | A | L | Wirt County | 47 | Tyler Consolidated | 81 | 714 | ||
| 2021-03-22 | H | W | Wirt County | 56 | Wood Co. Christian | 43 | 709 | ||
| 2021-03-23 | H | L | Wirt County | 33 | Williamstown | 59 | 702 | ||
| 2021-03-25 | A | L | Wirt County | 28 | St. Marys | 65 | 740 | ||
| 2021-03-30 | A | L | Wirt County | 34 | Ravenswood | 49 | 707 | ||
| 2021-04-01 | H | W | Wirt County | 71 | Parkersburg Catholic | 52 | 691 | ||
| 2021-04-03 | A | W | Wirt County | 70 | Calhoun County | 26 | 717 | ||
| 2021-04-06 | H | W | Wirt County | 69 | Wahama | 36 | 711 | ||
| 2021-04-08 | A | L | Wirt County | 38 | Roane County | 62 | LKC 11th | 1126 | |
| 2021-04-13 | H | W | Wirt County | 76 | Doddridge County | 29 | 718 | ||
| 2021-04-15 | H | W | Wirt County | 74 | Calhoun County | 40 | 716 | ||
| 2021-04-20 | H | W | Wirt County | 43 | Parkersburg Catholic | 40 | 1186 | ||
| 2021-04-23 | A | L | Wirt County | 34 | Williamstown | 76 | 1228 | ||
| 2021-04-29 | A | L | Wirt County | 33 | Ritchie County | 59 | 1273 |