| Date | H/A | W/L | Team | Score | Opponent | Score | |||
| 2021-03-05 | H | W | Clay County | 64 | Braxton County | 44 | 61 | ||
| 2021-03-06 | H | L | Clay County | 48 | Herbert Hoover | 56 | 62 | ||
| 2021-03-09 | H | W | Clay County | 58 | Roane County | 33 | 63 | ||
| 2021-03-15 | A | W | Clay County | 65 | Buffalo | 51 | 38 | ||
| 2021-03-16 | H | W | Clay County | 80 | Gilmer County | 44 | 65 | ||
| 2021-03-18 | A | W | Clay County | 67 | South Harrison | 62 | 779 | ||
| 2021-03-22 | H | W | Clay County | 83 | Webster County | 69 | 64 | ||
| 2021-03-25 | A | W | Clay County | 62 | Calhoun County | 19 | 780 | ||
| 2021-03-27 | H | L | Clay County | 60 | Buffalo | 66 | 67 | ||
| 2021-04-01 | A | W | Clay County | 60 | Roane County | 43 | 764 | ||
| 2021-04-06 | A | W | Clay County | 85 | Webster County | 76 | 1 OT | 781 | |
| 2021-04-08 | H | W | Clay County | 74 | Braxton County | 58 | 1138 | ||
| 2021-04-12 | N | L | Clay County | 44 | Williamstown | 55 | LKC Championship OT | 1121 | |
| 2021-04-23 | H | W | Clay County | 52 | Braxton County | 41 | 1230 | ||
| 2021-04-29 | H | W | Clay County | 70 | Frankfort | 60 | 1 OT | 1276 | |
| 2021-05-04 | H | L | Clay County | 38 | Chapmanville Regional | 46 | 1293 |