| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | H | W | Frontier (OH) | 34 | Bridgeport (OH) (3) | 20 | Hx 666 | |
| 2021-08-27 | H | W | Frontier (OH) | 34 | Paden City (2) | 0 | Hx 430 | |
| 2021-09-04 | A | W | Frontier (OH) | 33 | Racine Southern (OH) (4) | 0 | Hx 1141 | |
| 2021-09-10 | A | L | Frontier (OH) | 6 | Cameron (9) | 44 | Hx 402 | |
| 2021-09-17 | A | W | Frontier (OH) | 54 | Valley-Wetzel (3) | 12 | Hx 448 | |
| 2021-10-08 | H | W | Frontier (OH) | 28 | Magnolia (1) | 21 | Hx 422 | |
| 2021-10-15 | A | L | Frontier (OH) | 28 | Monroe Central (OH) (4) | 46 | Hx 714 | |
| 2021-10-22 | H | L | Frontier (OH) | 13 | River (OH) (6) | 56 | Hx 713 |