| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | L | Moorefield | 0 | Frankfort (6) | 19 | Hx 259 | |
| 2021-09-11 | A | W | Moorefield | 46 | Southern Garrett County (MD) (0) | 6 | Hx 427 | |
| 2021-09-17 | H | W | Moorefield | 45 | Tucker County (2) | 14 | Hx 579 | |
| 2021-09-24 | A | W | Moorefield | 41 | Petersburg (3) | 6 | Hx 580 | |
| 2021-09-28 | A | W | Moorefield | 54 | Pocahontas County (5) | 0 | Hx 578 | |
| 2021-10-08 | H | W | Moorefield | 22 | Northern Garrett County (MD) (4) | 13 | Hx 428 | |
| 2021-10-15 | A | W | Moorefield | 25 | East Hardy (10) | 24 | Hx 502 | |
| 2021-10-22 | A | L | Moorefield | 14 | Keyser (4) | 16 | Hx 295 | |
| 2021-10-28 | H | W | Moorefield | 40 | Pendleton County (2) | 0 | Hx 581 | |
| 2021-11-05 | H | L | Moorefield | 13 | Berkeley Springs (4) | 40 | Hx 203 | |
| 2021-11-13 | A | L | Moorefield | 7 | Wheeling Central (9) | 35 | 8-9 1st RD | Hx 1265 |