| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-09-03 | H | W | Keyser | 45 | Berkeley Springs (4) | 14 | Hx 196 | |
| 2021-09-17 | H | W | Keyser | 35 | Robert C. Byrd (7) | 13 | Hx 289 | |
| 2021-09-24 | A | W | Keyser | 50 | Hampshire (2) | 14 | Hx 83 | |
| 2021-10-01 | A | L | Keyser | 19 | Northern Garrett County (MD) (4) | 34 | Hx 291 | |
| 2021-10-08 | H | L | Keyser | 33 | Pt. Pleasant (8) | 35 | Hx 292 | |
| 2021-10-15 | A | L | Keyser | 14 | Allegany (MD) (6) | 31 | Hx 293 | |
| 2021-10-22 | H | W | Keyser | 16 | Moorefield (7) | 14 | Hx 295 | |
| 2021-10-25 | H | W | Keyser | 1 | Oak Glen (2) | 0 | Hx 1252 | |
| 2021-10-29 | A | L | Keyser | 8 | Mt. Ridge (MD) (7) | 33 | Hx 294 | |
| 2021-11-05 | H | L | Keyser | 35 | Frankfort (6) | 41 | Hx 263 |