| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Berkeley Springs | 56 | Petersburg (3) | 58 | Hx 195 | |
| 2021-09-03 | A | L | Berkeley Springs | 14 | Keyser (4) | 45 | Hx 196 | |
| 2021-09-11 | H | W | Berkeley Springs | 48 | Braxton County (1) | 20 | Hx 197 | |
| 2021-09-17 | A | L | Berkeley Springs | 26 | Frankfort (6) | 67 | Hx 198 | |
| 2021-09-24 | H | W | Berkeley Springs | 31 | Tucker County (2) | 28 | Hx 199 | |
| 2021-10-01 | H | L | Berkeley Springs | 31 | Oak Glen (2) | 53 | Hx 200 | |
| 2021-10-15 | H | W | Berkeley Springs | 71 | Hampshire (2) | 40 | Hx 85 | |
| 2021-10-22 | A | W | Berkeley Springs | 56 | East Fairmont (5) | 48 | Hx 201 | |
| 2021-10-29 | H | W | Berkeley Springs | 54 | Clear Spring (MD) (0) | 0 | Hx 202 | |
| 2021-11-05 | A | W | Berkeley Springs | 40 | Moorefield (7) | 13 | Hx 203 |