| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-09-03 | A | W | Mingo Central | 43 | Wyoming East (1) | 12 | Hx 324 | |
| 2021-09-10 | A | L | Mingo Central | 28 | Pt. Pleasant (8) | 66 | Hx 325 | |
| 2021-09-17 | A | L | Mingo Central | 6 | Man (4) | 7 | Hx 326 | |
| 2021-09-24 | H | L | Mingo Central | 13 | Poca (9) | 22 | Hx 327 | |
| 2021-10-01 | H | L | Mingo Central | 12 | Greenbrier East (6) | 55 | Hx 73 | |
| 2021-10-08 | H | W | Mingo Central | 65 | Tolsia (0) | 0 | Hx 329 | |
| 2021-10-15 | A | W | Mingo Central | 45 | Shady Spring (5) | 12 | Hx 328 | |
| 2021-10-22 | H | L | Mingo Central | 0 | Herbert Hoover (10) | 57 | Hx 277 | |
| 2021-10-29 | A | L | Mingo Central | 20 | Chapmanville Regional (3) | 35 | Hx 228 | |
| 2021-11-05 | A | L | Mingo Central | 6 | Bluefield (7) | 55 | Hx 210 |