| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-28 | H | W | Oak Glen | 35 | Weir (2) | 20 | Hx 342 | |
| 2021-09-17 | H | L | Oak Glen | 7 | Pt. Pleasant (8) | 42 | Hx 344 | |
| 2021-10-01 | A | W | Oak Glen | 53 | Berkeley Springs (4) | 31 | Hx 200 | |
| 2021-10-08 | A | L | Oak Glen | 14 | Brooke (3) | 21 | Hx 34 | |
| 2021-10-15 | H | L | Oak Glen | 13 | East Liverpool (OH) (3) | 34 | Hx 346 | |
| 2021-10-22 | H | L | Oak Glen | 6 | North Marion (8) | 60 | Hx 341 | |
| 2021-10-25 | A | L | Oak Glen | 0 | Keyser (4) | 1 | Hx 1252 | |
| 2021-10-29 | A | L | Oak Glen | 0 | John Marshall (3) | 42 | Hx 122 | |
| 2021-11-04 | H | L | Oak Glen | 17 | Wheeling Central (9) | 55 | Hx 1169 |