| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Wyoming East | 28 | Westside (1) | 6 | Hx 396 | |
| 2021-09-03 | H | L | Wyoming East | 12 | Mingo Central (2) | 43 | Hx 324 | |
| 2021-09-17 | A | L | Wyoming East | 6 | Herbert Hoover (10) | 70 | Hx 274 | |
| 2021-09-24 | A | L | Wyoming East | 8 | Nicholas County (6) | 53 | Hx 331 | |
| 2021-10-08 | H | L | Wyoming East | 0 | Shady Spring (5) | 6 | Hx 389 | |
| 2021-10-12 | A | L | Wyoming East | 13 | River View (4) | 36 | Hx 400 | |
| 2021-10-15 | H | L | Wyoming East | 0 | Pt. Pleasant (8) | 1 | Hx 361 | |
| 2021-10-22 | A | L | Wyoming East | 12 | PikeView (1) | 28 | Hx 354 | |
| 2021-10-29 | A | L | Wyoming East | 8 | Independence (8) | 60 | Hx 288 | |
| 2021-11-05 | H | L | Wyoming East | 6 | Liberty-Raleigh (6) | 54 | Hx 311 |