| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-26 | A | L | PikeView | 7 | Summers County (2) | 36 | Hx 349 | |
| 2021-09-03 | H | L | PikeView | 28 | Van (5) | 52 | Hx 350 | |
| 2021-10-01 | H | L | PikeView | 14 | James Monroe (8) | 62 | Hx 353 | |
| 2021-10-04 | H | L | PikeView | 6 | Westside (1) | 40 | Hx 351 | |
| 2021-10-11 | A | L | PikeView | 0 | Bluefield (7) | 66 | Hx 207 | |
| 2021-10-22 | H | W | PikeView | 28 | Wyoming East (1) | 12 | Hx 354 | |
| 2021-10-29 | H | W | PikeView | 36 | River View (4) | 26 | Hx 355 | |
| 2021-11-01 | A | L | PikeView | 0 | Liberty-Raleigh (6) | 1 | Hx 1261 | |
| 2021-11-02 | H | L | PikeView | 26 | Shady Spring (5) | 40 | Hx 352 | |
| 2021-11-05 | A | L | PikeView | 14 | Nicholas County (6) | 54 | Hx 335 |