| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Parkersburg | 7 | Huntington (13) | 47 | Hx 1 | |
| 2021-09-03 | H | L | Parkersburg | 10 | Spring Valley (8) | 34 | Hx 2 | |
| 2021-09-10 | H | W | Parkersburg | 28 | Capital (1) | 20 | Hx 3 | |
| 2021-09-17 | H | W | Parkersburg | 28 | Parkersburg South (5) | 19 | Hx 4 | |
| 2021-09-24 | A | L | Parkersburg | 6 | Cabell Midland (11) | 45 | Hx 5 | |
| 2021-10-01 | H | L | Parkersburg | 30 | Hurricane (5) | 42 | Hx 6 | |
| 2021-10-09 | A | L | Parkersburg | 21 | South Charleston (5) | 38 | Hx 7 | |
| 2021-10-22 | A | W | Parkersburg | 31 | Riverside (3) | 7 | Hx 8 | |
| 2021-10-29 | H | L | Parkersburg | 24 | George Washington (8) | 28 | Hx 9 | |
| 2021-11-05 | A | W | Parkersburg | 56 | Musselman (3) | 52 | Hx 10 |