| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Preston | 0 | Hampshire (2) | 21 | Hx 79 | |
| 2021-09-10 | H | L | Preston | 7 | John Marshall (3) | 48 | Hx 119 | |
| 2021-09-17 | H | L | Preston | 0 | Robert C. Byrd (7) | 1 | Hx 1180 | |
| 2021-09-24 | A | L | Preston | 0 | East Fairmont (5) | 1 | Hx 169 | |
| 2021-09-30 | A | L | Preston | 12 | North Marion (8) | 31 | Hx 167 | |
| 2021-10-08 | A | L | Preston | 0 | Bridgeport (8) | 72 | Hx 25 | |
| 2021-10-15 | H | L | Preston | 13 | Washington (5) | 14 | Hx 170 | |
| 2021-10-22 | H | L | Preston | 8 | University (10) | 56 | Hx 171 | |
| 2021-10-29 | A | W | Preston | 30 | Buckhannon-Upshur (0) | 14 | Hx 46 | |
| 2021-11-05 | A | L | Preston | 7 | Brooke (3) | 14 | Hx 38 |