| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | John Marshall | 0 | University (10) | 55 | Hx 117 | |
| 2021-09-03 | H | W | John Marshall | 36 | Weir (2) | 0 | Hx 118 | |
| 2021-09-10 | A | W | John Marshall | 48 | Preston (1) | 7 | Hx 119 | |
| 2021-09-17 | H | W | John Marshall | 34 | Trimble (OH) (7) | 33 | Hx 120 | |
| 2021-09-24 | A | L | John Marshall | 25 | Parkersburg South (5) | 28 | Hx 14 | |
| 2021-10-01 | A | W | John Marshall | 33 | Buckhannon-Upshur (0) | 14 | Hx 42 | |
| 2021-10-14 | H | W | John Marshall | 41 | Brooke (3) | 6 | Hx 35 | |
| 2021-10-22 | H | L | John Marshall | 7 | Morgantown (5) | 33 | Hx 121 | |
| 2021-10-29 | H | W | John Marshall | 42 | Oak Glen (2) | 0 | Hx 122 | |
| 2021-11-05 | H | L | John Marshall | 7 | Wheeling Park (3) | 35 | Hx 123 |