| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 0000-00-00 | H | University | Cabell Midland (11) | Quarterfinals OT Hx 1290 | ||||
| 2021-08-27 | H | W | University | 55 | John Marshall (3) | 0 | Hx 117 | |
| 2021-09-03 | H | W | University | 62 | Parkersburg South (5) | 33 | Hx 12 | |
| 2021-09-10 | A | W | University | 52 | Brooke (3) | 20 | Hx 31 | |
| 2021-09-18 | A | W | University | 35 | Wheeling Park (3) | 14 | Hx 190 | |
| 2021-09-24 | H | W | University | 35 | Fairmont Sr. (9) | 6 | Hx 191 | |
| 2021-10-08 | A | W | University | 36 | Albert Gallatin (PA) (1) | 14 | Hx 151 | |
| 2021-10-15 | A | W | University | 63 | Buckhannon-Upshur (0) | 6 | Hx 44 | |
| 2021-10-22 | A | W | University | 56 | Preston (1) | 8 | Hx 171 | |
| 2021-10-29 | H | W | University | 49 | Morgantown (5) | 14 | Hx 143 | |
| 2021-11-05 | H | W | University | 63 | Oak Hill (2) | 21 | Hx 166 | |
| 2021-11-12 | H | W | University | 52 | Woodrow Wilson (4) | 10 | 4-13 1st RD | Hx 1282 |
| 2021-11-19 | H | L | University | 21 | Cabell Midland (11) | 46 | Quarterfinals | Hx 1295 |