| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Brooke | 28 | Ripley (1) | 7 | Hx 29 | |
| 2021-09-02 | A | W | Brooke | 28 | Indian Creek (OH) (0) | 13 | Hx 30 | |
| 2021-09-10 | H | L | Brooke | 20 | University (10) | 52 | Hx 31 | |
| 2021-10-01 | H | W | Brooke | 30 | Marietta (OH) (1) | 21 | Hx 33 | |
| 2021-10-08 | H | W | Brooke | 21 | Oak Glen (2) | 14 | Hx 34 | |
| 2021-10-14 | A | L | Brooke | 6 | John Marshall (3) | 41 | Hx 35 | |
| 2021-10-22 | A | L | Brooke | 7 | Wheeling Park (3) | 56 | Hx 36 | |
| 2021-10-29 | A | L | Brooke | 6 | Weir (2) | 29 | Hx 37 | |
| 2021-11-05 | H | W | Brooke | 14 | Preston (1) | 7 | Hx 38 |