| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-30 | H | L | Capital | 28 | Parkersburg South (5) | 29 | Hx 11 | |
| 2021-09-04 | H | L | Capital | 21 | South Charleston (5) | 42 | Hx 56 | |
| 2021-09-10 | A | L | Capital | 20 | Parkersburg (4) | 28 | Hx 3 | |
| 2021-09-17 | A | W | Capital | 42 | Riverside (3) | 22 | Hx 57 | |
| 2021-09-24 | H | L | Capital | 7 | Huntington (13) | 30 | Hx 58 | |
| 2021-10-08 | H | L | Capital | 0 | Cabell Midland (11) | 14 | Hx 53 | |
| 2021-10-15 | H | L | Capital | 13 | Spring Valley (8) | 49 | Hx 59 | |
| 2021-10-22 | A | L | Capital | 6 | Hurricane (5) | 54 | Hx 60 | |
| 2021-10-29 | H | L | Capital | 19 | St. Albans (2) | 27 | Hx 61 | |
| 2021-11-05 | A | L | Capital | 0 | George Washington (8) | 41 | Hx 62 |