| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 0000-00-00 | A | Cabell Midland | University (10) | Quarterfinals OT Hx 1290 | ||||
| 2021-08-27 | A | W | Cabell Midland | 28 | Spring Valley (8) | 19 | Hx 48 | |
| 2021-09-03 | H | W | Cabell Midland | 56 | Riverside (3) | 0 | Hx 49 | |
| 2021-09-10 | A | L | Cabell Midland | 17 | Huntington (13) | 21 | Hx 50 | |
| 2021-09-17 | H | W | Cabell Midland | 44 | Hurricane (5) | 25 | Hx 51 | |
| 2021-09-24 | H | W | Cabell Midland | 45 | Parkersburg (4) | 6 | Hx 5 | |
| 2021-10-01 | A | W | Cabell Midland | 56 | Oak Hill (2) | 16 | Hx 52 | |
| 2021-10-08 | A | W | Cabell Midland | 14 | Capital (1) | 0 | Hx 53 | |
| 2021-10-15 | H | W | Cabell Midland | 35 | George Washington (8) | 7 | Hx 54 | |
| 2021-10-22 | A | W | Cabell Midland | 70 | Parkersburg South (5) | 21 | Hx 17 | |
| 2021-10-26 | A | Cabell Midland | Huntington (13) | Semifinals | Hx 1306 | |||
| 2021-11-05 | A | W | Cabell Midland | 55 | St. Albans (2) | 0 | Hx 55 | |
| 2021-11-12 | H | W | Cabell Midland | 49 | South Charleston (5) | 12 | 5-12 1st RD | Hx 1283 |
| 2021-11-19 | A | W | Cabell Midland | 46 | University (10) | 21 | Quarterfinals | Hx 1295 |
| 2021-11-26 | A | L | Cabell Midland | 15 | Huntington (13) | 37 | Semifinals | Hx 1315 |