| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 0000-00-00 | A | George Washington | Huntington (13) | Quarterfinals OT Hx 1289 | ||||
| 2021-08-26 | A | W | George Washington | 49 | St. Albans (2) | 0 | Hx 63 | |
| 2021-09-03 | A | W | George Washington | 35 | Ashland (KY) (5) | 21 | Hx 64 | |
| 2021-09-10 | H | W | George Washington | 35 | Hurricane (5) | 14 | Hx 65 | |
| 2021-09-17 | H | L | George Washington | 14 | Huntington (13) | 30 | Hx 66 | |
| 2021-10-01 | A | L | George Washington | 13 | South Charleston (5) | 14 | Hx 67 | |
| 2021-10-08 | H | W | George Washington | 49 | Riverside (3) | 0 | Hx 68 | |
| 2021-10-15 | A | L | George Washington | 7 | Cabell Midland (11) | 35 | Hx 54 | |
| 2021-10-22 | H | W | George Washington | 48 | Woodrow Wilson (4) | 35 | Hx 69 | |
| 2021-10-29 | A | W | George Washington | 28 | Parkersburg (4) | 24 | Hx 9 | |
| 2021-11-05 | H | W | George Washington | 41 | Capital (1) | 0 | Hx 62 | |
| 2021-11-12 | A | W | George Washington | 21 | Greenbrier East (6) | 7 | 8-9 1st RD | Hx 1281 |
| 2021-11-19 | A | L | George Washington | 13 | Huntington (13) | 29 | Quarterfinals | Hx 1294 |