| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-30 | A | W | Parkersburg South | 29 | Capital (1) | 28 | Hx 11 | |
| 2021-09-03 | A | L | Parkersburg South | 33 | University (10) | 62 | Hx 12 | |
| 2021-09-10 | H | W | Parkersburg South | 61 | Woodrow Wilson (4) | 13 | Hx 13 | |
| 2021-09-17 | A | L | Parkersburg South | 19 | Parkersburg (4) | 28 | Hx 4 | |
| 2021-09-24 | H | W | Parkersburg South | 28 | John Marshall (3) | 25 | Hx 14 | |
| 2021-10-15 | A | L | Parkersburg South | 14 | Morgantown (5) | 21 | Hx 16 | |
| 2021-10-22 | H | L | Parkersburg South | 21 | Cabell Midland (11) | 70 | Hx 17 | |
| 2021-10-29 | A | W | Parkersburg South | 26 | Wheeling Park (3) | 24 | Hx 18 | |
| 2021-11-01 | A | L | Parkersburg South | 0 | Bridgeport (8) | 1 | Hx 1259 | |
| 2021-11-05 | H | W | Parkersburg South | 44 | Princeton (4) | 34 | Hx 19 | |
| 2021-11-12 | A | L | Parkersburg South | 20 | Martinsburg (13) | 83 | 2-15 1st RD | Hx 1284 |