| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | W | South Charleston | 37 | Morgantown (5) | 28 | Hx 139 | |
| 2021-09-04 | A | W | South Charleston | 42 | Capital (1) | 21 | Hx 56 | |
| 2021-09-10 | H | W | South Charleston | 55 | St. Albans (2) | 0 | Hx 182 | |
| 2021-09-24 | A | L | South Charleston | 8 | Spring Valley (8) | 53 | Hx 183 | |
| 2021-10-01 | H | W | South Charleston | 14 | George Washington (8) | 13 | Hx 67 | |
| 2021-10-09 | H | W | South Charleston | 38 | Parkersburg (4) | 21 | Hx 7 | |
| 2021-10-15 | A | L | South Charleston | 14 | Riverside (3) | 22 | Hx 181 | |
| 2021-10-22 | H | L | South Charleston | 21 | Huntington (13) | 52 | Hx 101 | |
| 2021-10-29 | A | L | South Charleston | 27 | Hurricane (5) | 28 | Hx 106 | |
| 2021-11-05 | H | L | South Charleston | 21 | Woodrow Wilson (4) | 42 | Hx 184 | |
| 2021-11-12 | A | L | South Charleston | 12 | Cabell Midland (11) | 49 | 5-12 1st RD | Hx 1283 |