| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | H | W | Cambridge (OH) | 27 | Indian Creek (OH) (0) | 7 | Hx 724 | |
| 2021-09-18 | A | L | Cambridge (OH) | 14 | Bellaire (OH) (9) | 45 | Hx 672 | |
| 2021-09-24 | A | W | Cambridge (OH) | 23 | Martins Ferry (OH) (1) | 0 | Hx 746 | |
| 2021-10-08 | A | W | Cambridge (OH) | 42 | Warren Local (OH) (1) | 10 | Hx 859 | |
| 2021-10-15 | H | W | Cambridge (OH) | 49 | Marietta (OH) (1) | 13 | Hx 752 | |
| 2021-10-22 | A | L | Cambridge (OH) | 28 | St. Clairsville (OH) (4) | 55 | Hx 800 |