| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | H | L | Marietta (OH) | 7 | New Philadelphia (OH) (1) | 48 | Hx 747 | |
| 2021-08-27 | A | L | Marietta (OH) | 14 | River (OH) (6) | 35 | Hx 748 | |
| 2021-09-03 | H | W | Marietta (OH) | 36 | Athens (OH) (0) | 28 | Hx 749 | |
| 2021-09-10 | H | W | Marietta (OH) | 40 | Wright Charter (DC) (0) | 12 | Hx 750 | |
| 2021-09-17 | H | W | Marietta (OH) | 34 | Ripley (1) | 14 | Hx 148 | |
| 2021-09-24 | A | L | Marietta (OH) | 12 | Shenandoah (OH) (1) | 22 | Hx 1163 | |
| 2021-10-01 | A | L | Marietta (OH) | 21 | Brooke (3) | 30 | Hx 33 | |
| 2021-10-08 | A | L | Marietta (OH) | 0 | Dover (OH) (4) | 49 | Hx 751 | |
| 2021-10-15 | A | L | Marietta (OH) | 13 | Cambridge (OH) (3) | 49 | Hx 752 | |
| 2021-10-22 | H | W | Marietta (OH) | 20 | Warren Local (OH) (1) | 0 | Hx 753 |