| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Ripley | 7 | Brooke (3) | 28 | Hx 29 | |
| 2021-09-03 | H | W | Ripley | 31 | Buckhannon-Upshur (0) | 13 | Hx 39 | |
| 2021-09-10 | A | L | Ripley | 21 | Lincoln County (2) | 50 | Hx 126 | |
| 2021-09-17 | A | L | Ripley | 14 | Marietta (OH) (1) | 34 | Hx 148 | |
| 2021-09-24 | H | L | Ripley | 26 | Oak Hill (2) | 47 | Hx 163 | |
| 2021-10-01 | H | L | Ripley | 7 | Roane County (6) | 44 | Hx 174 | |
| 2021-10-08 | H | L | Ripley | 14 | St. Albans (2) | 26 | Hx 175 | |
| 2021-10-15 | H | L | Ripley | 7 | Greenbrier East (6) | 42 | Hx 75 | |
| 2021-10-22 | A | L | Ripley | 14 | Shady Spring (5) | 28 | Hx 176 | |
| 2021-10-29 | A | L | Ripley | 0 | Pt. Pleasant (8) | 51 | Hx 177 |