| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | A | L | Belpre (OH) | 12 | Warren Local (OH) (1) | 47 | Hx 854 | |
| 2021-09-10 | A | W | Belpre (OH) | 45 | Federal Hocking (OH) (0) | 0 | Hx 731 | |
| 2021-09-17 | A | L | Belpre (OH) | 36 | Racine Southern (OH) (4) | 73 | Hx 778 | |
| 2021-10-01 | A | L | Belpre (OH) | 12 | River (OH) (6) | 58 | Hx 792 | |
| 2021-10-08 | H | L | Belpre (OH) | 8 | Trimble (OH) (7) | 57 | Hx 833 | |
| 2021-10-15 | A | L | Belpre (OH) | 0 | Reedsville Eastern (OH) (4) | 46 | Hx 789 | |
| 2021-10-22 | H | L | Belpre (OH) | 8 | Waterford (OH) (6) | 55 | Hx 853 |