| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Paden City | 0 | Frontier (OH) () | 34 | 430 | |
| 2021-09-03 | A | W | Paden City | 58 | Hancock (MD) () | 0 | 431 | |
| 2021-09-10 | A | L | Paden City | 14 | Montcalm () | 20 | 574 | |
| 2021-09-24 | A | W | Paden City | 55 | Hundred () | 0 | 531 | |
| 2021-10-01 | H | L | Paden City | 13 | Calhoun County () | 44 | 475 | |
| 2021-10-06 | H | L | Paden City | 0 | Trinity () | 1 | 588 | |
| 2021-10-15 | A | L | Paden City | 14 | Beallsville (OH) () | 40 | 432 | |
| 2021-10-22 | H | L | Paden City | 8 | Bridgeport (OH) () | 50 | 433 | |
| 2021-10-29 | A | L | Paden City | 12 | Webster County () | 21 | 589 | |
| 2021-11-05 | H | L | Paden City | 20 | Valley-Wetzel () | 46 | 590 |