| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Cameron | 26 | West Greene (PA) () | 20 | 401 | |
| 2021-09-03 | H | W | Cameron | 82 | Hundred () | 0 | 480 | |
| 2021-09-10 | H | W | Cameron | 44 | Frontier (OH) () | 6 | 402 | |
| 2021-09-28 | A | W | Cameron | 38 | Madonna () | 20 | 482 | |
| 2021-10-01 | A | W | Cameron | 22 | Trinity () | 13 | 569 | |
| 2021-10-08 | A | W | Cameron | 62 | Valley-Wetzel () | 8 | 483 | |
| 2021-10-15 | H | W | Cameron | 44 | Clay-Battelle () | 0 | 484 | |
| 2021-10-22 | H | W | Cameron | 47 | Beallsville (OH) () | 0 | 403 | |
| 2021-10-29 | H | W | Cameron | 30 | Trinity () | 0 | 485 | |
| 2021-11-13 | H | L | Cameron | 14 | Gilmer County () | 19 | 1-16 1st RD | 1264 |