| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Tucker County | 14 | Pocahontas County () | 34 | 597 | |
| 2021-09-03 | H | W | Tucker County | 16 | Tygarts Valley () | 14 | 625 | |
| 2021-09-10 | A | L | Tucker County | 0 | East Hardy () | 46 | 499 | |
| 2021-09-17 | A | L | Tucker County | 14 | Moorefield () | 45 | 579 | |
| 2021-09-24 | A | L | Tucker County | 28 | Berkeley Springs () | 31 | 199 | |
| 2021-10-01 | H | W | Tucker County | 14 | Pendleton County () | 0 | 592 | |
| 2021-10-15 | H | L | Tucker County | 6 | Southern Garrett County (MD) () | 28 | 444 | |
| 2021-10-22 | A | L | Tucker County | 20 | Gilmer County () | 26 | 510 | |
| 2021-10-29 | H | L | Tucker County | 14 | Petersburg () | 18 | 596 | |
| 2021-11-05 | H | L | Tucker County | 24 | South Harrison () | 36 | 621 |