| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | L | Moorefield | 0 | Frankfort () | 19 | 259 | |
| 2021-09-11 | A | W | Moorefield | 46 | Southern Garrett County (MD) () | 6 | 427 | |
| 2021-09-17 | H | W | Moorefield | 45 | Tucker County () | 14 | 579 | |
| 2021-09-24 | A | W | Moorefield | 41 | Petersburg () | 6 | 580 | |
| 2021-09-28 | A | W | Moorefield | 54 | Pocahontas County () | 0 | 578 | |
| 2021-10-08 | H | W | Moorefield | 22 | Northern Garrett County (MD) () | 13 | 428 | |
| 2021-10-15 | A | W | Moorefield | 25 | East Hardy () | 24 | 502 | |
| 2021-10-22 | A | L | Moorefield | 14 | Keyser () | 16 | 295 | |
| 2021-10-28 | H | W | Moorefield | 40 | Pendleton County () | 0 | 581 | |
| 2021-11-05 | H | L | Moorefield | 13 | Berkeley Springs () | 40 | 203 | |
| 2021-11-13 | A | L | Moorefield | 7 | Wheeling Central () | 35 | 8-9 1st RD | 1265 |