| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | L | Gilmer County | 20 | East Hardy () | 41 | 498 | |
| 2021-09-03 | A | W | Gilmer County | 54 | Webster County () | 14 | 506 | |
| 2021-09-10 | A | W | Gilmer County | 39 | Wirt County () | 12 | 507 | |
| 2021-09-17 | H | W | Gilmer County | 40 | Wahama () | 20 | 508 | |
| 2021-09-24 | A | W | Gilmer County | 39 | South Harrison () | 20 | 509 | |
| 2021-10-18 | A | W | Gilmer County | 46 | Calhoun County () | 0 | 476 | |
| 2021-10-22 | H | W | Gilmer County | 26 | Tucker County () | 20 | 510 | |
| 2021-10-26 | A | L | Gilmer County | 0 | Doddridge County () | 1 | 1255 | |
| 2021-10-29 | H | L | Gilmer County | 15 | Ritchie County () | 43 | 511 | |
| 2021-11-05 | A | L | Gilmer County | 14 | Meadow Bridge () | 24 | 512 | |
| 2021-11-13 | A | W | Gilmer County | 19 | Cameron () | 14 | 1-16 1st RD | 1264 |
| 2021-11-20 | A | L | Gilmer County | 0 | Wheeling Central () | 55 | Quarterfinals | 1303 |