| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-28 | H | L | Calhoun County | 8 | Wirt County () | 54 | 470 | |
| 2021-09-03 | H | W | Calhoun County | 28 | Valley-Wetzel () | 6 | 471 | |
| 2021-09-20 | A | L | Calhoun County | 14 | Tyler Consolidated () | 46 | 473 | |
| 2021-09-24 | H | L | Calhoun County | 0 | St. Marys () | 48 | 474 | |
| 2021-10-01 | A | W | Calhoun County | 44 | Paden City () | 13 | 475 | |
| 2021-10-18 | H | L | Calhoun County | 0 | Gilmer County () | 46 | 476 | |
| 2021-10-23 | A | L | Calhoun County | 14 | Wahama () | 48 | 477 | |
| 2021-10-27 | A | L | Calhoun County | 0 | Doddridge County () | 1 | 1254 | |
| 2021-10-29 | H | L | Calhoun County | 14 | Clay-Battelle () | 28 | 478 | |
| 2021-11-05 | H | L | Calhoun County | 20 | Ritchie County () | 45 | 479 |