| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | L | Man | 14 | Logan () | 21 | 317 | |
| 2021-09-10 | A | W | Man | 49 | Westside () | 14 | 397 | |
| 2021-09-17 | H | W | Man | 7 | Mingo Central () | 6 | 326 | |
| 2021-09-24 | A | L | Man | 21 | Wheeling Central () | 49 | 547 | |
| 2021-10-01 | H | W | Man | 20 | Buffalo () | 6 | 464 | |
| 2021-10-05 | H | L | Man | 21 | Mt. View () | 45 | 546 | |
| 2021-10-15 | A | L | Man | 7 | Independence () | 74 | 286 | |
| 2021-10-22 | A | L | Man | 14 | Pt. Pleasant () | 41 | 362 | |
| 2021-10-29 | H | W | Man | 35 | Tug Valley () | 28 | 548 | |
| 2021-11-05 | A | L | Man | 28 | Chapmanville Regional () | 40 | 229 |