| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Berkeley Springs | 56 | Petersburg () | 58 | 195 | |
| 2021-09-03 | A | L | Berkeley Springs | 14 | Keyser () | 45 | 196 | |
| 2021-09-11 | H | W | Berkeley Springs | 48 | Braxton County () | 20 | 197 | |
| 2021-09-17 | A | L | Berkeley Springs | 26 | Frankfort () | 67 | 198 | |
| 2021-09-24 | H | W | Berkeley Springs | 31 | Tucker County () | 28 | 199 | |
| 2021-10-01 | H | L | Berkeley Springs | 31 | Oak Glen () | 53 | 200 | |
| 2021-10-15 | H | W | Berkeley Springs | 71 | Hampshire () | 40 | 85 | |
| 2021-10-22 | A | W | Berkeley Springs | 56 | East Fairmont () | 48 | 201 | |
| 2021-10-29 | H | W | Berkeley Springs | 54 | Clear Spring (MD) () | 0 | 202 | |
| 2021-11-05 | A | W | Berkeley Springs | 40 | Moorefield () | 13 | 203 |